Publications

Axiom-2 Scientific Results

Outcomes of the experiments performed for SOMA during the Axiom Space Ax-2 mission to the International Space Station.

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Shirah, B., Overbey, E. G., Foox, J., Hirschberg, J. W., Kim, J., Ryon, K., Proszynski, J., Meydan, C., Najjar, D., Collier, P., LeRoy, E., Pandya, S., Gonzalez, Y., Persad, A. H., Ahmed, M. M., Bukhari, H., Naseer, M. I., Ashemimry, M. N., Taylor, L., . . . Mason, C. E. (2025). Telomere length dynamics associated with short-duration human spaceflight. Neuroscience Research in Short-Duration Human Spaceflight, 125-143.

Shirah, B., Zu Eulenburg, P., Overbey, E. G., Kim, J., Burke, M., Hirschberg, J. W., Schulze, I., Ryon, K., Proszynski, J., Meydan, C., Najjar, D., Foox, J., Collier, P., Nelson, T. M., Zhang, D. J., Iyoha, N. M., Jones, C. J., Przywozny, B., Sibilly, T., . . . Mason, C. E. (2025). Surrogate assessment of brain health using longitudinal measures of blood-based biomarkers in short-duration human spaceflight. Neuroscience Research in Short-Duration Human Spaceflight, 101-124.

Shirah, B., Mason, C. E., Overbey, E. G., Kim, J., Pandya, S., Gonzalez, Y., Persad, A. H., Ahmed, M. M., Ashemimry, M. N., Naseer, M. I., & Sen, J. (2025). Unlocking the neurological mysteries of space from Saudi Arabia’s inaugural human spaceflight mission (Axiom Mission 2): Pioneering insights, novel tools, and pathways to safer future space exploration. Neuroscience Research in Short-Duration Human Spaceflight, 1-20.

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Inspiration4 Scientific Results

Outcomes of the scientific experiments performed during the SpaceX Inspiration4 mission, the first all-civilian mission to orbit.

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Rutter, L. A., MacKay, M. J., Cope, H., Szewczyk, N. J., Kim, J., Overbey, E. G., Tierney, B. T., Muratani, M., Lamm, B., Bezdan, D., Paul, A. M., Schmidt, M. A., Church, G. M., Giacomello, S., & Mason, C. E. (2024). Protective alleles and precision healthcare in crewed spaceflight. Nature Communications, 15(1), 1-13.

Mason, C. E., Green, J., Adamopoulos, K. I., Afshin, E. E., Baechle, J. J., Basner, M., Bailey, S. M., Bielski, L., Borg, J., Borg, J., Broddrick, J. T., Burke, M., Caicedo, A., Castañeda, V., Chatterjee, S., Chin, C. R., Church, G., Costes, S. V., De Vlaminck, I., . . .Overbey E. G., . . . Beheshti, A. (2024). A second space age spanning omics, platforms and medicine across orbits. Nature, 632(8027), 995-1008.

Sanders, L. M., Grigorev, K. A., Scott, R. T., M., A., Polo, S., Gilbert, R., Overbey, E. G., Kim, J., Mason, C. E., & Costes, S. V. (2024). Inspiration4 data access through the NASA Open Science Data Repository. Npj Microgravity, 10(1), 1-7.

Jones, C. W., Overbey, E. G., Lacombe, J., Ecker, A. J., Meydan, C., Ryon, K., Tierney, B., Damle, N., MacKay, M., Afshin, E. E., Foox, J., Park, J., Nelson, T. M., Suhail Mohamad, M., Byhaqui, S. G., Aslam, B., Tali, U. A., Nisa, L., Menon, P. V., . . . Mason, C. E. (2024). Molecular and physiological changes in the SpaceX Inspiration4 civilian crew. Nature, 632(8027), 1155-1164.

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Space Omics and Medical Atlas Release

Release of the Space Omics and Medical Atlas (SOMA), which created >90% of all astronaut omics data, and the Cornell Aerospace Medicine Biobank (CAMbank), the first publicly available astronaut biobank.

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Overbey, E. G., Ryon, K., Kim, J., Tierney, B. T., Klotz, R., Ortiz, V., Mullane, S., Schmidt, J. C., MacKay, M., Damle, N., Najjar, D., Matei, I., Patras, L., Garcia Medina, J. S., Kleinman, A. S., Wain Hirschberg, J., Proszynski, J., Narayanan, S. A., Schmidt, C. M., . . . Mason, C. E. (2024). Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA). Nature Communications, 15(1), 1-14.

Park, J., Overbey, E. G., Narayanan, S. A., Kim, J., Tierney, B. T., Damle, N., Najjar, D., Ryon, K. A., Proszynski, J., Kleinman, A., Hirschberg, J. W., MacKay, M., Afshin, E. E., Granstein, R., Gurvitch, J., Hudson, B. M., Rininger, A., Mullane, S., Church, S. E., . . . Mason, C. E. (2024). Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight. Nature Communications, 15(1), 1-14.

Kim, J., Tierney, B. T., Overbey, E. G., Dantas, E., Fuentealba, M., Park, J., Narayanan, S. A., Wu, F., Najjar, D., Chin, C. R., Meydan, C., Loy, C., Mathyk, B., Klotz, R., Ortiz, V., Nguyen, K., Ryon, K. A., Damle, N., Houerbi, N., . . . Mason, C. E. (2024). Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight. Nature Communications, 15(1), 1-18.

Grigorev, K., Nelson, T. M., Overbey, E. G., Houerbi, N., Kim, J., Najjar, D., Damle, N., Afshin, E. E., Ryon, K. A., Melnick, A. M., Mateus, J., & Mason, C. E. (2024). Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses. Nature Communications, 15(1), 1-11.

Tierney, B. T., Kim, J., Overbey, E. G., Ryon, K. A., Foox, J., Sierra, M. A., Bhattacharya, C., Damle, N., Najjar, D., Park, J., Garcia Medina, J. S., Houerbi, N., Meydan, C., Wain Hirschberg, J., Qiu, J., Kleinman, A. S., A., G., MacKay, M., Afshin, E. E., . . . Mason, C. E. (2024). Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight. Nature Microbiology, 9(7), 1661-1675.

Houerbi, N., Kim, J., Overbey, E. G., Batra, R., Schweickart, A., Patras, L., Lucotti, S., Ryon, K. A., Najjar, D., Meydan, C., Damle, N., Chin, C., Narayanan, S. A., Guarnieri, J. W., Widjaja, G., Beheshti, A., Tobias, G., Vatter, F., Hirschberg, J. W., . . . Mason, C. E. (2024). Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight. Nature Communications, 15(1), 1-17.

Overbey, E. G., Kim, J., Tierney, B. T., Park, J., Houerbi, N., Lucaci, A. G., Garcia Medina, S., Damle, N., Najjar, D., Grigorev, K., Afshin, E. E., Ryon, K. A., Sienkiewicz, K., Patras, L., Klotz, R., Ortiz, V., MacKay, M., Schweickart, A., Chin, C. R., . . . Mason, C. E. (2024). The Space Omics and Medical Atlas (SOMA) and international astronaut biobank. Nature, 632(8027), 1145-1154.

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Chronological Publication List